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Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Yuk, Soon Hong | - |
| dc.contributor.author | Oh, Keun Sang | - |
| dc.contributor.author | Koo, Heebeom | - |
| dc.contributor.author | Jeon, Hyesung | - |
| dc.contributor.author | Kim, Kwangmeyung | - |
| dc.contributor.author | Kwon, Ick Chan | - |
| dc.date.accessioned | 2021-09-07T06:25:27Z | - |
| dc.date.available | 2021-09-07T06:25:27Z | - |
| dc.date.created | 2021-06-19 | - |
| dc.date.issued | 2011-11 | - |
| dc.identifier.issn | 0142-9612 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111175 | - |
| dc.description.abstract | The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology. (C) 2011 Elsevier Ltd. All rights reserved. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | ELSEVIER SCI LTD | - |
| dc.subject | POLYETHYLENE-GLYCOL | - |
| dc.subject | LIPOSOME FUSION | - |
| dc.subject | LUNG-CANCER | - |
| dc.subject | DOCETAXEL | - |
| dc.subject | PACLITAXEL | - |
| dc.subject | BILAYER | - |
| dc.subject | INCREASES | - |
| dc.subject | RELEASE | - |
| dc.title | Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Yuk, Soon Hong | - |
| dc.contributor.affiliatedAuthor | Kwon, Ick Chan | - |
| dc.identifier.doi | 10.1016/j.biomaterials.2011.07.017 | - |
| dc.identifier.scopusid | 2-s2.0-80051817296 | - |
| dc.identifier.wosid | 000295072600018 | - |
| dc.identifier.bibliographicCitation | BIOMATERIALS, v.32, no.31, pp.7924 - 7931 | - |
| dc.relation.isPartOf | BIOMATERIALS | - |
| dc.citation.title | BIOMATERIALS | - |
| dc.citation.volume | 32 | - |
| dc.citation.number | 31 | - |
| dc.citation.startPage | 7924 | - |
| dc.citation.endPage | 7931 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Engineering | - |
| dc.relation.journalResearchArea | Materials Science | - |
| dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
| dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
| dc.subject.keywordPlus | POLYETHYLENE-GLYCOL | - |
| dc.subject.keywordPlus | LIPOSOME FUSION | - |
| dc.subject.keywordPlus | LUNG-CANCER | - |
| dc.subject.keywordPlus | DOCETAXEL | - |
| dc.subject.keywordPlus | PACLITAXEL | - |
| dc.subject.keywordPlus | BILAYER | - |
| dc.subject.keywordPlus | INCREASES | - |
| dc.subject.keywordPlus | RELEASE | - |
| dc.subject.keywordAuthor | Drug delivery | - |
| dc.subject.keywordAuthor | Multi-core vesicle nanoparticles | - |
| dc.subject.keywordAuthor | Pluronic | - |
| dc.subject.keywordAuthor | Docetaxel | - |
| dc.subject.keywordAuthor | Chemotherapy | - |
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Related Researcher
- Yuk, Soon Hong
- College of Pharmacy (Department of Pharmaceutical Science)