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Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs

Authors
Yuk, Soon HongOh, Keun SangKoo, HeebeomJeon, HyesungKim, KwangmeyungKwon, Ick Chan
Issue Date
11월-2011
Publisher
ELSEVIER SCI LTD
Keywords
Drug delivery; Multi-core vesicle nanoparticles; Pluronic; Docetaxel; Chemotherapy
Citation
BIOMATERIALS, v.32, no.31, pp.7924 - 7931
Indexed
SCIE
SCOPUS
Journal Title
BIOMATERIALS
Volume
32
Number
31
Start Page
7924
End Page
7931
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/111175
DOI
10.1016/j.biomaterials.2011.07.017
ISSN
0142-9612
Abstract
The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology. (C) 2011 Elsevier Ltd. All rights reserved.
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College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles

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