Fermentation of Korean Red Ginseng by Lactobacillus plantarum M-2 and Its Immunological Activities
DC Field | Value | Language |
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dc.contributor.author | Kim, Bong-Gwan | - |
dc.contributor.author | Shin, Kwang-Soon | - |
dc.contributor.author | Yoon, Taek Joon | - |
dc.contributor.author | Yu, Kwang-Won | - |
dc.contributor.author | Ra, Kyung Soo | - |
dc.contributor.author | Kim, Jin Man | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-07T06:26:15Z | - |
dc.date.available | 2021-09-07T06:26:15Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.issn | 0273-2289 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111179 | - |
dc.description.abstract | We investigated ginsenoside transformation by fermentation of red ginseng with Lactobacillus plantarum M-2. We also examined the anti-metastasis and immune-stimulating activities of EtOH extracts of fermented red ginseng (FRG-E) in animal and human subjects. Total sugar decreased from 85.5 mg mL(-1) to 44.1 mg mL(-1) with increasing culture time during the fermentation with L. plantarum M-2. Uronic acid content reached a maximum level (534.3 mu g mL(-1)) at 3 days of fermentation and decreased thereafter. Ginsenoside metabolites increased from 4,637.0 to 7,581.1 mu g mL(-1) after 4 days. The prophylactic intraperitoneal injection of FRG-E (500 mu g mouse(-1)) inhibited lung metastasis about 81.1%, while the inhibitory effect against tumor metastasis by treatment of EtOH extract from non-fermented red ginseng (NFRG-E) was 66.9%. Immunoglobulin A (IgA) and G (IgG) levels in the serum of healthy subjects were higher after FRG-E administration than at baseline, whereas NFRG-E induced reductions of these variables related to immunity. At 1 week, the change in IgA level by FRG-E (5.14 mg mL(-1)) was significantly higher than that by NFRG-E (-14.50 mg mL(-1); p < 0.05). It was concluded that the immunological activities of FRG-E were higher than those of NFRG-E, indicating that fermentation helped enhance the immunological activities of red ginseng. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HUMANA PRESS INC | - |
dc.subject | HUMAN INTESTINAL BACTERIA | - |
dc.subject | TUMOR-METASTASIS | - |
dc.subject | BIOLOGICAL-ACTIVITIES | - |
dc.subject | MICE | - |
dc.subject | SAPONINS | - |
dc.subject | PROTOPANAXADIOL | - |
dc.subject | GINSENOSIDES | - |
dc.subject | DEGRADATION | - |
dc.subject | METABOLISM | - |
dc.subject | ACTIVATION | - |
dc.title | Fermentation of Korean Red Ginseng by Lactobacillus plantarum M-2 and Its Immunological Activities | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1007/s12010-011-9328-6 | - |
dc.identifier.scopusid | 2-s2.0-81955168028 | - |
dc.identifier.wosid | 000297222400001 | - |
dc.identifier.bibliographicCitation | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, v.165, no.5-6, pp.1107 - 1119 | - |
dc.relation.isPartOf | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | - |
dc.citation.title | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | - |
dc.citation.volume | 165 | - |
dc.citation.number | 5-6 | - |
dc.citation.startPage | 1107 | - |
dc.citation.endPage | 1119 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | HUMAN INTESTINAL BACTERIA | - |
dc.subject.keywordPlus | TUMOR-METASTASIS | - |
dc.subject.keywordPlus | BIOLOGICAL-ACTIVITIES | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | SAPONINS | - |
dc.subject.keywordPlus | PROTOPANAXADIOL | - |
dc.subject.keywordPlus | GINSENOSIDES | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Korean red ginseng | - |
dc.subject.keywordAuthor | Fermentation | - |
dc.subject.keywordAuthor | Lactobacillus plantarum | - |
dc.subject.keywordAuthor | Immunological activity | - |
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