Analysis of Pulsatile and Nonpulsatile Blood Flow Effects in Different Degrees of Stenotic Vasculature
- Authors
- Jung, Jae Seung; Son, Kuk Hui; Ahn, Chi Bum; Lee, Jung Joo; Son, Ho Sung; Sun, Kyung
- Issue Date
- 11월-2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- Pulsatile flow; Extracorporeal circulation; Hemodynamic energy; Diameter stenosis
- Citation
- ARTIFICIAL ORGANS, v.35, no.11, pp.1118 - 1122
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARTIFICIAL ORGANS
- Volume
- 35
- Number
- 11
- Start Page
- 1118
- End Page
- 1122
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111213
- DOI
- 10.1111/j.1525-1594.2011.01361.x
- ISSN
- 0160-564X
- Abstract
- Vessel lumens that have been chronically narrowed by atherosclerosis should be increased in flow velocity and intrastenotic area pressure to maintain an equal flow. This might be followed by a decrease in hemodynamic energy, leading to a reduction of tissue perfusion. In this study, we compared hemodynamic energies according to degrees of stenotic vasculature between pulsatile flow and nonpulsatile flow. Cannuale with 25, 50, and 75% diameter stenosis (DS) were located at the outlet cannula. Using the Korea Hybrid ventricular assist device (KH-VAD) (pulsatile pump: group A) and Biopump (nonpulsatile pump: group B), constant flow of 2 L/min was maintained then real-time flow and velocity in the proximal and distal part of the stenotic cannula were measured. The hemodynamic energies of two groups were compared. At 75% DS, proximal energy equivalent pressure (EEP) delivered to the distal end was only 41.9% (group A) and 42.5% (group B). As the percent EEP fell below 10%, pulsatility disappeared from the 50% stenosis in group A. The surplus hemodynamic energy (SHE) of group B at all degrees of stenosis must have been 0, which was also the case of group A at 75% stenosis. This research evaluated the hemodynamic energy on various degrees of DS in both pulsatile and nonpulsatile flow with mock system. Using a pulsatile pump, pulsatility disappeared above 50% DS while hemodynamic energy was maintained. Therefore, our results suggest that pulsatile flow has a better effect than nonpulsatile flow in reserving hemodynamic energy after stenotic lesion.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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