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An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells
- Issue Date
- Nov-2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- Embryonic stem cell; Endothelial cell differentiation; Integrated microfluidic device
- Citation
- ELECTROPHORESIS, v.32, no.22, pp.3133 - 3137
- Indexed
- SCIE
SCOPUS
- Journal Title
- ELECTROPHORESIS
- Volume
- 32
- Number
- 22
- Start Page
- 3133
- End Page
- 3137
- ISSN
- 0173-0835
- Abstract
- We developed an integrated microfluidic culture device to regulate embryonic stem (ES) cell fate. The integrated microfluidic culture device consists of an air control channel and a fluidic channel with 4 x 4 micropillar arrays. We hypothesized that the microscale posts within the micropillar arrays would enable the control of uniform cell docking and shear stress profiles. We demonstrated that ES cells cultured for 6 days in the integrated microfluidic culture device differentiated into endothelial cells. Therefore, our integrated microfluidic culture device is a potentially powerful tool for directing ES cell fate.
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Collections - College of Health Sciences > School of Biomedical Engineering > 1. Journal Articles
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