Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4(+) Cell Properties during Viral Infection
DC Field | Value | Language |
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dc.contributor.author | Marshall, Heather D. | - |
dc.contributor.author | Chandele, Anmol | - |
dc.contributor.author | Jung, Yong Woo | - |
dc.contributor.author | Meng, Hailong | - |
dc.contributor.author | Poholek, Amanda C. | - |
dc.contributor.author | Parish, Ian A. | - |
dc.contributor.author | Rutishauser, Rachel | - |
dc.contributor.author | Cui, Weiguo | - |
dc.contributor.author | Kleinstein, Steven H. | - |
dc.contributor.author | Craft, Joe | - |
dc.contributor.author | Kaech, Susan M. | - |
dc.date.accessioned | 2021-09-07T06:55:29Z | - |
dc.date.available | 2021-09-07T06:55:29Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-10-28 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111344 | - |
dc.description.abstract | CD4(+) T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4(+) T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8(+) T cells, increased IL-7R expression was not a reliable marker of CD4(+) memory precursor cells. However, decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C(lo)T-bet(int) Th1 effector cells was virtually identical to mature memory CD4(+) T cells, indicating early maturation of memory CD4(+) T cell features in this subset during acute viral infection. This study provides a framework for memory CD4(+) T cell development after acute viral infection. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | SURVIVAL | - |
dc.subject | ANTIGEN | - |
dc.subject | IL-7 | - |
dc.subject | TRANSITION | - |
dc.subject | ALPHA | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | REGULATORS | - |
dc.subject | MIGRATION | - |
dc.subject | RESPONSES | - |
dc.subject | SUBSETS | - |
dc.title | Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4(+) Cell Properties during Viral Infection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Yong Woo | - |
dc.identifier.doi | 10.1016/j.immuni.2011.08.016 | - |
dc.identifier.scopusid | 2-s2.0-80755163540 | - |
dc.identifier.wosid | 000296657700021 | - |
dc.identifier.bibliographicCitation | IMMUNITY, v.35, no.4, pp.633 - 646 | - |
dc.relation.isPartOf | IMMUNITY | - |
dc.citation.title | IMMUNITY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 633 | - |
dc.citation.endPage | 646 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | IL-7 | - |
dc.subject.keywordPlus | TRANSITION | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | REGULATORS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | SUBSETS | - |
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