Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4(+) Cell Properties during Viral Infection
- Authors
- Marshall, Heather D.; Chandele, Anmol; Jung, Yong Woo; Meng, Hailong; Poholek, Amanda C.; Parish, Ian A.; Rutishauser, Rachel; Cui, Weiguo; Kleinstein, Steven H.; Craft, Joe; Kaech, Susan M.
- Issue Date
- 28-10월-2011
- Publisher
- CELL PRESS
- Citation
- IMMUNITY, v.35, no.4, pp.633 - 646
- Indexed
- SCIE
SCOPUS
- Journal Title
- IMMUNITY
- Volume
- 35
- Number
- 4
- Start Page
- 633
- End Page
- 646
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111344
- DOI
- 10.1016/j.immuni.2011.08.016
- ISSN
- 1074-7613
- Abstract
- CD4(+) T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4(+) T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8(+) T cells, increased IL-7R expression was not a reliable marker of CD4(+) memory precursor cells. However, decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C(lo)T-bet(int) Th1 effector cells was virtually identical to mature memory CD4(+) T cells, indicating early maturation of memory CD4(+) T cell features in this subset during acute viral infection. This study provides a framework for memory CD4(+) T cell development after acute viral infection.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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