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Transcranial focused ultrasound to the thalamus alters anesthesia time in rats

Authors
Yoo, Seung-SchikKim, HyungminMin, Byoung-KyongFranck, EricPark, Shinsuk
Issue Date
26-10월-2011
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
anesthesia; brain; function; focused ultrasound; neuromodulation; ultrasound
Citation
NEUROREPORT, v.22, no.15, pp.783 - 787
Indexed
SCIE
SCOPUS
Journal Title
NEUROREPORT
Volume
22
Number
15
Start Page
783
End Page
787
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/111348
DOI
10.1097/WNR.0b013e32834b2957
ISSN
0959-4965
Abstract
A pulsed application of focused ultrasound (FUS) to the regional brain tissue alters the state of tissue excitability and thus provides the means for noninvasive functional neuromodulation. We report that the application of transcranial FUS to the thalamus of anesthetized rats reduced the time to emergence of voluntary movement from intraperitoneal ketamine/xylazine anesthesia. Low-intensity FUS was applied to the thalamus of anesthetized animals. The times required for the animals to show distinct physiological/behavioral changes were measured and compared with those times required in a control session without sonication. The sonication significantly reduced the time to show pinch response and voluntary movement. The modulatory effects of FUS on anesthesia suggest potential therapeutic applications for disorders of consciousness such as minimally consciousness states. NeuroReport 22:783-787 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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