Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2-and ubiquitin-dependent mechanisms
DC Field | Value | Language |
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dc.contributor.author | Cho, Sung-Yun | - |
dc.contributor.author | Jun, Hee-jin | - |
dc.contributor.author | Lee, Ji Hae | - |
dc.contributor.author | Jia, Yaoyao | - |
dc.contributor.author | Kim, Kyoung Heon | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.date.accessioned | 2021-09-07T07:05:46Z | - |
dc.date.available | 2021-09-07T07:05:46Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2011-10-20 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111359 | - |
dc.description.abstract | We investigated hypocholesterolemic mechanisms of linalool, an aromatic anti-oxidative monoterpene, which is abundant in teas and essential oils. Oral administration of linalool to mice for 6 weeks significantly lowered total and low-density lipoprotein cholesterol concentrations, and HMG-CoA reductase protein expression (-46%; P < 0.05) by both transcriptional and posttranscriptional mechanisms. Linalool suppressed the gene expression of HMG-CoA reductase by reducing the binding of SREBP-2 to its promoter, as assessed by qPCR and chromatin immunoprecipitation, and by inducing ubiquitin-dependent proteolysis of the HMG-CoA reductase. These findings suggest that food molecules with a pleasant scent could exert beneficial metabolic effects through multiple mechanisms. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | FEEDBACK-REGULATION | - |
dc.subject | LIPID-SYNTHESIS | - |
dc.subject | ESSENTIAL OILS | - |
dc.subject | GREEN TEA | - |
dc.subject | DEGRADATION | - |
dc.subject | CHOLESTEROL | - |
dc.subject | (-)-LINALOOL | - |
dc.subject | METAANALYSIS | - |
dc.subject | LANOSTEROL | - |
dc.subject | RISK | - |
dc.title | Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2-and ubiquitin-dependent mechanisms | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kyoung Heon | - |
dc.contributor.affiliatedAuthor | Lee, Sung-Joon | - |
dc.identifier.doi | 10.1016/j.febslet.2011.09.012 | - |
dc.identifier.scopusid | 2-s2.0-80054065083 | - |
dc.identifier.wosid | 000296514100022 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.585, no.20, pp.3289 - 3296 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 585 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 3289 | - |
dc.citation.endPage | 3296 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | FEEDBACK-REGULATION | - |
dc.subject.keywordPlus | LIPID-SYNTHESIS | - |
dc.subject.keywordPlus | ESSENTIAL OILS | - |
dc.subject.keywordPlus | GREEN TEA | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | (-)-LINALOOL | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | LANOSTEROL | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Cholesterol | - |
dc.subject.keywordAuthor | HMG-CoA reductase | - |
dc.subject.keywordAuthor | Sterol regulatory element binding protein-2 | - |
dc.subject.keywordAuthor | Ubiquitination | - |
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