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Two-Photon Lysotrackers for in Vivo Imaging
- Authors
- Son, Ji Hoon; Lim, Chang Su; Han, Ji Hee; Danish, Isravel Antony; Kim, Hwan Myung; Cho, Bong Rae
- Issue Date
- 7-Oct-2011
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF ORGANIC CHEMISTRY, v.76, no.19, pp.8113 - 8116
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 76
- Number
- 19
- Start Page
- 8113
- End Page
- 8116
- ISSN
- 0022-3263
- Abstract
- We report two-photon Lysotrackers (CLT-blue and CLT-yellow) that can be excited by 750-840 nm femto-second laser pulses and emit at 470 and 550 nm, respectively. They can be easily loaded into cells and tissue slices for visualization of lysosomes in live cells and tissues for a long period of time through two-photon microscopy. When combined with appropriate two-photon probes for other biological targets, these novel probes would greatly facilitate the two-photon microscopy colocalization experiments.
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