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Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jia, Yaoyao | - |
| dc.contributor.author | Bhuiyan, Muhammad Javidul Haque | - |
| dc.contributor.author | Jun, Hee-jin | - |
| dc.contributor.author | Lee, Ji Hae | - |
| dc.contributor.author | Hoang, Minh Hien | - |
| dc.contributor.author | Lee, Hak-Ju | - |
| dc.contributor.author | Kim, Nahyun | - |
| dc.contributor.author | Lee, Dongho | - |
| dc.contributor.author | Hwang, Kwang Yeon | - |
| dc.contributor.author | Hwang, Bang Yeon | - |
| dc.contributor.author | Choi, Dal-Woong | - |
| dc.contributor.author | Lee, Sung-Joon | - |
| dc.date.accessioned | 2021-09-07T07:37:27Z | - |
| dc.date.available | 2021-09-07T07:37:27Z | - |
| dc.date.created | 2021-06-19 | - |
| dc.date.issued | 2011-10-01 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111397 | - |
| dc.description.abstract | In this study, we confirmed that ursolic acid, a plant triterpenoid, activates peroxisome proliferator-activated receptor (PPAR)-alpha in vitro. Surface plasmon resonance and time-resolved fluorescence resonance energy transfer analyses do not show direct binding of ursolic acid to the ligand-binding domain of PPAR-alpha; however, ursolic acid enhances the binding of PPAR-alpha to the peroxisome proliferator response element in PPAR-alpha-responsive genes, alters the expression of key genes in lipid metabolism, significantly reducing intracellular triglyceride and cholesterol concentrations in hepatocytes. Thus, ursolic acid is a PPAR-alpha agonist that regulates the expression of lipid metabolism genes, but it is not a direct ligand of PPAR-alpha. (C) 2011 Elsevier Ltd. All rights reserved. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.subject | PROLIFERATOR-ACTIVATED-RECEPTOR | - |
| dc.subject | OLEANOLIC ACID | - |
| dc.subject | GENE | - |
| dc.subject | TRANSCRIPTION | - |
| dc.subject | CHOLESTEROL | - |
| dc.subject | PATHWAYS | - |
| dc.subject | GAMMA | - |
| dc.title | Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Lee, Dongho | - |
| dc.contributor.affiliatedAuthor | Choi, Dal-Woong | - |
| dc.contributor.affiliatedAuthor | Lee, Sung-Joon | - |
| dc.identifier.doi | 10.1016/j.bmcl.2011.07.095 | - |
| dc.identifier.scopusid | 2-s2.0-80052566061 | - |
| dc.identifier.wosid | 000294714400047 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.19, pp.5876 - 5880 | - |
| dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 21 | - |
| dc.citation.number | 19 | - |
| dc.citation.startPage | 5876 | - |
| dc.citation.endPage | 5880 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | PROLIFERATOR-ACTIVATED-RECEPTOR | - |
| dc.subject.keywordPlus | OLEANOLIC ACID | - |
| dc.subject.keywordPlus | GENE | - |
| dc.subject.keywordPlus | TRANSCRIPTION | - |
| dc.subject.keywordPlus | CHOLESTEROL | - |
| dc.subject.keywordPlus | PATHWAYS | - |
| dc.subject.keywordPlus | GAMMA | - |
| dc.subject.keywordAuthor | Ursolic acid | - |
| dc.subject.keywordAuthor | PPAR-alpha | - |
| dc.subject.keywordAuthor | Agonist | - |
| dc.subject.keywordAuthor | Lipid metabolism | - |
| dc.subject.keywordAuthor | Hepatocyte | - |
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Related Researcher
- Lee, Sung Joon
- College of Life Sciences and Biotechnology (Division of Food Bioscience and Technology)