Assessment of Bronchodilator Responsiveness Following Methacholine-Induced Bronchoconstriction in Children With Asthma
- Authors
- Bauer, Siegfried; Park, Ha Neul; Seo, Hyun Suk; Kim, Ji Eun; Song, Dae Jin; Park, Sang Hee; Choung, Ji Tae; Yoo, Young; Kim, Hyung Jin
- Issue Date
- 10월-2011
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- Atopy; asthma; beta-adrenergic agonist; child; eosinophilia; methacholine
- Citation
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.3, no.4, pp.245 - 250
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
- Volume
- 3
- Number
- 4
- Start Page
- 245
- End Page
- 250
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111482
- DOI
- 10.4168/aair.2011.3.4.245
- ISSN
- 2092-7355
- Abstract
- Purpose: The aim of this study was to investigate bronchodilator responsiveness (BDR) following methacholine-induced bronchoconstriction and to determine differences in BDR according to clinical parameters in children with asthma. Methods: The methacholine challenge test was performed in 145 children with mild to moderate asthma, and the provocative concentration causing a 20% decline in FEV1 (PC20) was determined. Immediately after the challenge test, patients were asked to inhale short-acting beta 2-agonists (SABAs) to achieve BDR, which was assessed as the change in FEV1% predicted x 100/post-methacholine FEV1% predicted. For each subject, the asthma medication, blood eosinophil count, serum total IgE, serum eosinophil cationic protein level, and skin prick test result were assessed. Results: The FEV1 (mean +/- SD) values of the 145 patients were 90.5 +/- 10.9% predicted, 64.2 +/- 11.5% predicted, and 86.2 +/- 11.2% predicted before and after methacholine inhalation, and following the administration of a SABA, respectively. The BDR did not differ significantly according to asthma medication, age, or gender. However, BDR in the atopy group (37.4 +/- 17.7%) was significantly higher than that in the non-atopy group (30.5 +/- 10.7%; P=0.037). Patients with blood eosinophilia (38.6 +/- 18.1%) displayed increased BDR compared with patients without eosinophilia (32.0 +/- 13.8%; P=0.037). Conclusions: In children with mild to moderate asthma, the responsiveness to short-acting bronchodilators after methacholine-induced bronchoconstriction was not related to asthma medication, but was higher in children with atopy and/or peripheral blood eosinophilia.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.