No correlation between COMT genotype and entacapone benefits in Parkinson's disease
- Authors
- Kim, Ji Seon; Kim, Ji-Young; Kim, Jong-Min; Kim, Jae Woo; Chung, Sun Ju; Kim, Sung R.; Kim, Mi J.; Kim, Hee-Tae; Choi, Kyoung-Gyu; Shin, Dong-Ick; Sung, Young Hee; Lee, Kwang-Soo; Kim, Han-Joon; Cho, Jinwhan; Park, Mee Young; Park, Hyun-Young; Choi, Seong-Min; Park, Kun-Woo; Lee, Ho-Won; Ahn, Tae-Beom; Kwon, Oh Dae; Kim, Sang-Jin; Jeon, Beom S.
- Issue Date
- 9월-2011
- Publisher
- ASEAN NEUROLOGICAL ASSOC
- Citation
- NEUROLOGY ASIA, v.16, no.3, pp.211 - 216
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROLOGY ASIA
- Volume
- 16
- Number
- 3
- Start Page
- 211
- End Page
- 216
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111620
- ISSN
- 1823-6138
- Abstract
- Catechol-O-methyltransferase (COMT) inhibitors are used to increase the bioavailability of therapeutic L-dopa. We examined the efficacy of entacapone in Parkinson's disease patients who had daily "off" duration of <= 2 hours, and carried different COMT polymorphisms. A total of 168 PD patients were recruited from 19 centers. Subjects were administered with 100-200 mg of entacapone in combination with each dose of L-dopa for 2 months. The clinical efficacy was evaluated based on the activities of daily living (ADL), score on the Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr (H&Y) stage, and Clinical Global Impression (CGI). COMT polymorphisms were genotyped. 3-O-methyldopa (3-OMD) levels were measured before and after the administration of entacapone. Entacapone administration produced significant improvements in the total daily "on" duration, ADL, UPDRS score, and H&Y stage. Nineteen patients (11.3%) had the low-activity COMT genotype, 68 patients (40.5%) had the intermediate-activity COMT genotype, and 81patients (48.2%) had the high-activity COMT genotype. The efficacy, and adverse effects of entacapone therapy did not differ between the three groups. There was a significant reduction in 3-OMD, but this did not differ among the three genotypes. Entacapone provided an increased "on" duration and improved motor function in all COMT genotypes.
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