Plasma or Serum TIMP-1 is a Predictor of Survival Outcomes in Colorectal Cancer: a Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Ju-Han | - |
dc.contributor.author | Choi, Jung-Woo | - |
dc.contributor.author | Kim, Young-Sik | - |
dc.date.accessioned | 2021-09-07T08:45:28Z | - |
dc.date.available | 2021-09-07T08:45:28Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 1841-8724 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111657 | - |
dc.description.abstract | Background & Aims. Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a small secretory glycoprotein with anti-apoptosis and anti-matrix metalloproteinase activity. There have been some discordant data regarding the value of TIMP-1 as a prognostic factor in colorectal cancer (CRC) patients. To address this controversy, we conducted a meta-analysis for the relationship between TIMP-1 levels and overall survival in CRC. Methods. We selected the relevant published studies using citation databases including PubMed, Science Citation Index, and Conference Papers Index. The effect sizes of TIMP-1 on the patient's overall survival and TNM stages were calculated by hazard ratio (HR) or odds ratio (OR), respectively. The effect sizes were combined using a random-effects model. Results. Survival outcomes between high and low plasma or serum TEMP-1 levels were compared by uni- and multivariate analyses involving 1,477 and 1,359 CRC patients, respectively. CRC patients with high plasma or serum TIMP-1 levels showed poor survival rates compared to patients with low plasma or serum TIMP-1 in the uni- and multivariate analyses (HR, 2.2 and 2.1; P<0.001). In addition, high TIMP-1 expression in colon cancer tissues was significantly associated with worse survival outcomes in 438 CRC patients (HR = 1.4; P = 0.017). Conclusion. Plasma or serum TIMP-1 levels predict survival outcomes of CRC patients | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MEDICAL UNIV PRESS | - |
dc.subject | BREAST EPITHELIAL-CELLS | - |
dc.subject | TISSUE INHIBITOR | - |
dc.subject | METALLOPROTEINASES-1 TIMP-1 | - |
dc.subject | MATRIX METALLOPROTEINASE-1 | - |
dc.subject | PATIENT SURVIVAL | - |
dc.subject | CARCINOMA | - |
dc.subject | EXPRESSION | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | ASSOCIATIONS | - |
dc.subject | STATISTICS | - |
dc.title | Plasma or Serum TIMP-1 is a Predictor of Survival Outcomes in Colorectal Cancer: a Meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ju-Han | - |
dc.contributor.affiliatedAuthor | Choi, Jung-Woo | - |
dc.contributor.affiliatedAuthor | Kim, Young-Sik | - |
dc.identifier.scopusid | 2-s2.0-80053542909 | - |
dc.identifier.wosid | 000295813300012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES, v.20, no.3, pp.287 - 291 | - |
dc.relation.isPartOf | JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES | - |
dc.citation.title | JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES | - |
dc.citation.volume | 20 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 287 | - |
dc.citation.endPage | 291 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | BREAST EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | TISSUE INHIBITOR | - |
dc.subject.keywordPlus | METALLOPROTEINASES-1 TIMP-1 | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASE-1 | - |
dc.subject.keywordPlus | PATIENT SURVIVAL | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ASSOCIATIONS | - |
dc.subject.keywordPlus | STATISTICS | - |
dc.subject.keywordAuthor | TIMP-1 | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | survival | - |
dc.subject.keywordAuthor | meta-analysis | - |
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