Plasma or Serum TIMP-1 is a Predictor of Survival Outcomes in Colorectal Cancer: a Meta-analysis
- Authors
- Lee, Ju-Han; Choi, Jung-Woo; Kim, Young-Sik
- Issue Date
- 9월-2011
- Publisher
- MEDICAL UNIV PRESS
- Keywords
- TIMP-1; colorectal cancer; survival; meta-analysis
- Citation
- JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES, v.20, no.3, pp.287 - 291
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
- Volume
- 20
- Number
- 3
- Start Page
- 287
- End Page
- 291
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111657
- ISSN
- 1841-8724
- Abstract
- Background & Aims. Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a small secretory glycoprotein with anti-apoptosis and anti-matrix metalloproteinase activity. There have been some discordant data regarding the value of TIMP-1 as a prognostic factor in colorectal cancer (CRC) patients. To address this controversy, we conducted a meta-analysis for the relationship between TIMP-1 levels and overall survival in CRC. Methods. We selected the relevant published studies using citation databases including PubMed, Science Citation Index, and Conference Papers Index. The effect sizes of TIMP-1 on the patient's overall survival and TNM stages were calculated by hazard ratio (HR) or odds ratio (OR), respectively. The effect sizes were combined using a random-effects model. Results. Survival outcomes between high and low plasma or serum TEMP-1 levels were compared by uni- and multivariate analyses involving 1,477 and 1,359 CRC patients, respectively. CRC patients with high plasma or serum TIMP-1 levels showed poor survival rates compared to patients with low plasma or serum TIMP-1 in the uni- and multivariate analyses (HR, 2.2 and 2.1; P<0.001). In addition, high TIMP-1 expression in colon cancer tissues was significantly associated with worse survival outcomes in 438 CRC patients (HR = 1.4; P = 0.017). Conclusion. Plasma or serum TIMP-1 levels predict survival outcomes of CRC patients
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.