Significance of smoking history and FDG uptake for pathological N2 staging in clinical N2-negative non-small-cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Na, I. I. | - |
dc.contributor.author | Park, J. Y. | - |
dc.contributor.author | Kim, K. M. | - |
dc.contributor.author | Cheon, G. J. | - |
dc.contributor.author | Choe, D. H. | - |
dc.contributor.author | Koh, J. S. | - |
dc.contributor.author | Baek, H. J. | - |
dc.contributor.author | Lee, J. C. | - |
dc.date.accessioned | 2021-09-07T08:49:16Z | - |
dc.date.available | 2021-09-07T08:49:16Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 0923-7534 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111677 | - |
dc.description.abstract | Background: This study was conducted to evaluate whether smoking history and the standardized uptake value (SUV) of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) uptake are associated with unexpected pathological N2 status (pN2) in non-small-cell lung cancer (NSCLC). Patients and methods: We analyzed the data of 220 patients who underwent surgical resection with clinical N2-negative status on computed tomography (CT) and positron emission tomography (PET)-CT. The maximum SUV of primary tumor was chosen for logistic analysis. Results: Seventy-two patients (33%) had never smoked. The SUV ranged from 1.0 to 29.0 (median 9.1). In univariate analysis, adenocarcinomas (P = 0.019), female gender (P = 0.010), N1 on CT (P = 0.025), and N1 PET-CT (P = 0.001) were associated with a high probability of pN2. The proportion of pN2 in never smokers was higher than in ever smokers (26% versus 10% respectively; P = 0.002). The SUV remained on a multivariate logistic model (odds ratio 1.1; 95% confidence interval 1.0-1.2; P = 0.010) and it had a better predictive value in never smokers than in ever smokers (P = 0.017). Conclusions: This study indicates an association between smoking history and pN2 in clinically negative N2 NSCLC. The different roles of FDG uptake were also suggested based on smoking history. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | STANDARDIZED UPTAKE VALUE | - |
dc.subject | NEVER-SMOKERS | - |
dc.subject | COMPUTED-TOMOGRAPHY | - |
dc.subject | MEDIASTINAL METASTASES | - |
dc.subject | PET-CT | - |
dc.subject | ACCURACY | - |
dc.subject | SURVIVAL | - |
dc.subject | DISEASE | - |
dc.title | Significance of smoking history and FDG uptake for pathological N2 staging in clinical N2-negative non-small-cell lung cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cheon, G. J. | - |
dc.identifier.doi | 10.1093/annonc/mdq693 | - |
dc.identifier.scopusid | 2-s2.0-80052405144 | - |
dc.identifier.wosid | 000294495100017 | - |
dc.identifier.bibliographicCitation | ANNALS OF ONCOLOGY, v.22, no.9, pp.2068 - 2072 | - |
dc.relation.isPartOf | ANNALS OF ONCOLOGY | - |
dc.citation.title | ANNALS OF ONCOLOGY | - |
dc.citation.volume | 22 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2068 | - |
dc.citation.endPage | 2072 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | STANDARDIZED UPTAKE VALUE | - |
dc.subject.keywordPlus | NEVER-SMOKERS | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | MEDIASTINAL METASTASES | - |
dc.subject.keywordPlus | PET-CT | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | N2 | - |
dc.subject.keywordAuthor | non-small-cell lung cancer | - |
dc.subject.keywordAuthor | positron emission tomography | - |
dc.subject.keywordAuthor | smoking history | - |
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