Significance of smoking history and FDG uptake for pathological N2 staging in clinical N2-negative non-small-cell lung cancer
- Authors
- Na, I. I.; Park, J. Y.; Kim, K. M.; Cheon, G. J.; Choe, D. H.; Koh, J. S.; Baek, H. J.; Lee, J. C.
- Issue Date
- 9월-2011
- Publisher
- OXFORD UNIV PRESS
- Keywords
- N2; non-small-cell lung cancer; positron emission tomography; smoking history
- Citation
- ANNALS OF ONCOLOGY, v.22, no.9, pp.2068 - 2072
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF ONCOLOGY
- Volume
- 22
- Number
- 9
- Start Page
- 2068
- End Page
- 2072
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111677
- DOI
- 10.1093/annonc/mdq693
- ISSN
- 0923-7534
- Abstract
- Background: This study was conducted to evaluate whether smoking history and the standardized uptake value (SUV) of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) uptake are associated with unexpected pathological N2 status (pN2) in non-small-cell lung cancer (NSCLC). Patients and methods: We analyzed the data of 220 patients who underwent surgical resection with clinical N2-negative status on computed tomography (CT) and positron emission tomography (PET)-CT. The maximum SUV of primary tumor was chosen for logistic analysis. Results: Seventy-two patients (33%) had never smoked. The SUV ranged from 1.0 to 29.0 (median 9.1). In univariate analysis, adenocarcinomas (P = 0.019), female gender (P = 0.010), N1 on CT (P = 0.025), and N1 PET-CT (P = 0.001) were associated with a high probability of pN2. The proportion of pN2 in never smokers was higher than in ever smokers (26% versus 10% respectively; P = 0.002). The SUV remained on a multivariate logistic model (odds ratio 1.1; 95% confidence interval 1.0-1.2; P = 0.010) and it had a better predictive value in never smokers than in ever smokers (P = 0.017). Conclusions: This study indicates an association between smoking history and pN2 in clinically negative N2 NSCLC. The different roles of FDG uptake were also suggested based on smoking history.
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