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Aptamers-in-Liposomes for Selective and Multiplexed Capture of Small Organic Compounds

Authors
Kim, Yeon SeokNiazi, Javed H.Chae, Yun JuKo, U-RiGu, Man Bock
Issue Date
3-8월-2011
Publisher
WILEY-V C H VERLAG GMBH
Keywords
aptamers; liposomes; nanocomposites; selective capture; separation techniques
Citation
MACROMOLECULAR RAPID COMMUNICATIONS, v.32, no.15, pp.1169 - 1173
Indexed
SCIE
SCOPUS
Journal Title
MACROMOLECULAR RAPID COMMUNICATIONS
Volume
32
Number
15
Start Page
1169
End Page
1173
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/111812
DOI
10.1002/marc.201100177
ISSN
1022-1336
Abstract
Small, organic, toxic compounds are not well eliminated by water-treatment systems and eventually become concentrated in the human body. In this study, liposomes are employed to house aptamers with their own binding buffer. When small, organic, toxic compounds in water pass through a liposome barrier, only the target molecules are captured by the DNA aptamers inside the liposomes. The capture efficiency is not high when DNA aptamers are used in tap water. When DNA aptamers in liposomes are used, the capture efficiency increases more than 80%. The simultaneous and selective elimination of target toxicants is successfully performed for tap-water samples containing toxicant mixtures.
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