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Ratiometric Detection of Mitochondrial Thiols with a Two-Photon Fluorescent Probe
- Authors
- Lim, Chang Su; Masanta, Goutam; Kim, Hyung Joong; Han, Ji Hee; Kim, Hwan Myung; Cho, Bong Rae
- Issue Date
- 27-7월-2011
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, no.29, pp.11132 - 11135
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Volume
- 133
- Number
- 29
- Start Page
- 11132
- End Page
- 11135
- ISSN
- 0002-7863
- Abstract
- We report a ratiometric two-photon probe (SSH-Mito) for mitochondrial thiols. This probe shows a marked blue-to-yellow emission color change in response to RSH, a significant two-photon cross section, good mitochondrial thiol selectivity, low cytotoxicity, and insensitivity to pH over the biologically relevant pH range, allowing the direct visualization of RSH levels in live cells as well as in living tissues at 90-190 mu m depth without interference from other biologically relevant species through the use of two-photon microscopy.
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