Relationship between dietary folate intake and plasma monocyte chemoattractant protein-1 and interleukin-8 in heart failure patients
- Authors
- Chung, Hye Kyung; Kim, Oh Yoen; Lee, Hyeran; Do, Hyun Joo; Kim, Young Soon; Oh, Jaewon; Kang, Seok-Min; Shin, Min-Jeong
- Issue Date
- 1-7월-2011
- Publisher
- JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
- Keywords
- dietary folate; inflammation; heart failure; interleukin-8; MCP-1
- Citation
- JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, v.49, no.1, pp.62 - 66
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Volume
- 49
- Number
- 1
- Start Page
- 62
- End Page
- 66
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112020
- DOI
- 10.3164/jcbn.10-129
- ISSN
- 0912-0009
- Abstract
- This study aimed to examine the association of dietary vitamin intakes with plasma pro-inflammatory cytokine levels in Korean heart failure patients. Stable outpatients with heart failure were recruited and finally 91 patients were included. Dietary intakes were estimated by a developed semi-quantitative food frequency questionnaire. The simultaneous measurement of 17 cytokines was performed along with analysis of plasma C-reactive protein. Plasma C-reactive protein levels significantly correlated with dietary intakes of vitamin C (r = -0.30, p<0.005), beta-carotene (r = -0.23, p<0.05), and folate (r = -0.31, p<0.005). However, these associations were no longer significant after adjusting for traditional risk factors for heart failure. On the other hand, plasma levels of monocyte chemoattractant protein-1 significantly correlated with dietary folate intake (r = -0.31, p<0.001), and plasma interleukin-8 levels significantly correlated with dietary intakes of vitamin C (r = -0.38, p<0.001), beta-carotene (r = -0.42, p<0.001), and folate (r = -0.38, p<0.001) after the adjustment. Dietary folate intake was found as a primary influencing factor on plasma levels of monocyte chemoattractant protein-1 (p<0.005, R-2 = 0.20) and interleukin-8 (p<0.001, R-2 = 0.32) through a stepwise multiple linear regression analysis. Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure.
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