Romo1 is a negative-feedback regulator of Myc
- Authors
- Lee, Seung Baek; Kim, Jung Jin; Chung, Jin Sil; Lee, Myeong-Sok; Lee, Kee-Ho; Kim, Byung Soo; Tansey, William P.; Yoo, Young Do
- Issue Date
- 1-6월-2011
- Publisher
- COMPANY OF BIOLOGISTS LTD
- Keywords
- Myc; Romo1; ROS; Skp2
- Citation
- JOURNAL OF CELL SCIENCE, v.124, no.11, pp.1911 - 1924
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CELL SCIENCE
- Volume
- 124
- Number
- 11
- Start Page
- 1911
- End Page
- 1924
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112259
- DOI
- 10.1242/jcs.079996
- ISSN
- 0021-9533
- Abstract
- Degradation of Myc protein is mediated by E3 ubiquitin ligases, including SCF(Fbw7) and SCF(Skp2), but much remains unknown about the mechanism of S-phase kinase-associated protein (Skp2)-mediated Myc degradation. In the present study, we show that upregulated Myc protein, which triggers the G1-S phase progression in response to growth-stimulatory signals, induces reactive oxygen species modulator 1 (Romo1) expression. Romo1 subsequently triggers Skp2-mediated ubiquitylation and degradation of Myc by a mechanism not previously reported in normal lung fibroblasts. We also show that reactive oxygen species (ROS) derived from steady-state Romo1 expression are necessary for cell cycle entry of quiescent cells. From this study, we suggest that the generation of ROS mediated by pre-existing Romo1 protein is required for Myc induction. Meanwhile, Romo1 expression induced by Myc during G1 phase stimulates Skp2-mediated Myc degradation in a negative-feedback mechanism.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- Graduate School > Department of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholar.korea.ac.kr/handle/2021.sw.korea/112259)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.