Effects of Capsaicin on Lipid Catabolism in 3T3-L1 Adipocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Mak-Soon | - |
dc.contributor.author | Kim, Chong-Tai | - |
dc.contributor.author | Kim, In-Hwan | - |
dc.contributor.author | Kim, Yangha | - |
dc.date.accessioned | 2021-09-07T12:10:59Z | - |
dc.date.available | 2021-09-07T12:10:59Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112387 | - |
dc.description.abstract | Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a pungent ingredient of red peppers, and has been reported to reduce body weight gain and adiposity in rodents. The present study investigated the effects of capsaicin on lipid catabolism in differentiated 3T3-L1 adipocytes. Capsaicin decreased the intracellular lipid content in a concentration-dependent manner. The release of glycerol into the medium was increased by the addition of capsaicin. The mRNA levels of genes involved in lipid catabolism such as hormone sensitive lipase (HSL), carnitine palmitoyl transferase-I alpha (CPTI-alpha) and uncoupling protein 2 (UCP2) were up-regulated significantly. These results suggest that capsaicin exerts its lipolytic action by increasing the hydrolysis of triacylglycerol in adipocytes, and that these effects are mediated at least partially by regulation of the expression of multiple genes that are involved in the lipid catabolic pathway, such as HSL and CPT-I alpha, and those involved in thermogenesis such as UCP2. Copyright (C) 2010 John Wiley & Sons, Ltd. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | HORMONE-SENSITIVE LIPASE | - |
dc.subject | PUNGENT PRINCIPLE | - |
dc.subject | CAPSICUM FRUITS | - |
dc.subject | BODY-WEIGHT | - |
dc.subject | RED-PEPPER | - |
dc.subject | ADIPOGENESIS | - |
dc.subject | METABOLISM | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.subject | OXIDATION | - |
dc.title | Effects of Capsaicin on Lipid Catabolism in 3T3-L1 Adipocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, In-Hwan | - |
dc.identifier.doi | 10.1002/ptr.3339 | - |
dc.identifier.scopusid | 2-s2.0-79957836042 | - |
dc.identifier.wosid | 000291060700024 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, v.25, no.6, pp.935 - 939 | - |
dc.relation.isPartOf | PHYTOTHERAPY RESEARCH | - |
dc.citation.title | PHYTOTHERAPY RESEARCH | - |
dc.citation.volume | 25 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 935 | - |
dc.citation.endPage | 939 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | HORMONE-SENSITIVE LIPASE | - |
dc.subject.keywordPlus | PUNGENT PRINCIPLE | - |
dc.subject.keywordPlus | CAPSICUM FRUITS | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | RED-PEPPER | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordAuthor | capsaicin | - |
dc.subject.keywordAuthor | lipid catabolism | - |
dc.subject.keywordAuthor | glycerol release | - |
dc.subject.keywordAuthor | mRNA | - |
dc.subject.keywordAuthor | 3T3-L1 adipocytes | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.