Lipid-Soluble Ginseng Extract Induces Apoptosis and G0/G1 Cell Cycle Arrest in NCI-H460 Human Lung Cancer Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Moo Rim | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Lee, Sung Dong | - |
dc.contributor.author | Hyun, Dong-Hoon | - |
dc.contributor.author | In, Man-Jin | - |
dc.contributor.author | Park, Song-Kyu | - |
dc.contributor.author | Kim, Dong Chung | - |
dc.date.accessioned | 2021-09-07T12:12:44Z | - |
dc.date.available | 2021-09-07T12:12:44Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 0921-9668 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112397 | - |
dc.description.abstract | This study was performed to elucidate the anticancer mechanism of a lipid-soluble ginseng extract (LSGE) by analyzing induction of apoptosis and arrest of cell cycle progression using the NCI-H460 human lung cancer cell line. Proliferation of NCI-H460 cells was potently inhibited by LSGE in a dose-dependent manner. The cell cycle arrest at the G0/G1 phase in NCI-H460 cells was induced by LSGE. The percentage of G0/G1 phase cells significantly increased, while that of S phase cells decreased after treatment with LSGE. The expression levels of cyclin-dependent kinase2 (CDK2), CDK4, CDK6, cyclin D3 and cyclin E related to G0/G1 cells progression were also altered by LSGE. In addition, LSGE-induced cell death occurred through apoptosis, which was accompanied by increasing the activity of caspases including caspase-8, caspase-9 and caspase-3. Consistent with enhancement of caspase activity, LSGE increased protein levels of cleaved caspase-3, caspase-8, caspase-9, and poly-ADP-ribose polymerase (PARP). These apoptotic effects of LSGE were inhibited by the pan-caspase inhibitor Z-VAD-fmk. These findings indicate that LSGE inhibits NCI-H460 human lung cancer cell growth by cell cycle arrest at the G0/G1 phase and induction of caspase-mediated apoptosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | PROLIFERATION | - |
dc.subject | CYTOTOXICITY | - |
dc.title | Lipid-Soluble Ginseng Extract Induces Apoptosis and G0/G1 Cell Cycle Arrest in NCI-H460 Human Lung Cancer Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Song-Kyu | - |
dc.identifier.doi | 10.1007/s11130-011-0232-6 | - |
dc.identifier.scopusid | 2-s2.0-79960243414 | - |
dc.identifier.wosid | 000293978000002 | - |
dc.identifier.bibliographicCitation | PLANT FOODS FOR HUMAN NUTRITION, v.66, no.2, pp.101 - 106 | - |
dc.relation.isPartOf | PLANT FOODS FOR HUMAN NUTRITION | - |
dc.citation.title | PLANT FOODS FOR HUMAN NUTRITION | - |
dc.citation.volume | 66 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 106 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordAuthor | Apoptosis induction | - |
dc.subject.keywordAuthor | Caspase activation | - |
dc.subject.keywordAuthor | Human lung cancer cell | - |
dc.subject.keywordAuthor | G0/G1 phase arrest | - |
dc.subject.keywordAuthor | Lipid-soluble ginseng extract | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.