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Two-Photon Probes for Zn2+ Ions with Various Dissociation Constants. Detection of Zn2+ Ions in Live Cells and Tissues by Two-Photon Microscopy
- Authors
- Danish, Isravel Antony; Lim, Chang Su; Tian, Yu Shun; Han, Ji Hee; Kang, Min Young; Cho, Bong Rae
- Issue Date
- 2-May-2011
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- fluorescence; fluorescent probes; live tissue; two-photon microscopy; zinc
- Citation
- CHEMISTRY-AN ASIAN JOURNAL, v.6, no.5, pp.1234 - 1240
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMISTRY-AN ASIAN JOURNAL
- Volume
- 6
- Number
- 5
- Start Page
- 1234
- End Page
- 1240
- ISSN
- 1861-4728
- Abstract
- A series of Zn2+-selective two-photon fluorescent probes (AZn-M1-AZnN)that had a wide range of dissociation constants (K-d(TP) = 8 nm-12 mu m) were synthesized. These probes showed appreciable water solubility (> 3 mu m), cell permeability, high photo-stability, pH insensitivity at pH > 7, significant two-photon action cross-sections (86-110 GM) upon complexation with Zn2+, and can detect the Zn2+ ions in HeLa cells and in living tissue slices of rat hippocampal at a depth of > 80 mu m without mistargeting and photobleaching problems. These probes can potentially find application in the detection of various amounts of Zn2+ ions in live cells and intact tissues.
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