Hepatocellular carcinoma during pregnancy: is hepatocellular carcinoma more aggressive in pregnant patients?
- Authors
- Choi, Kang Kook; Hong, Young Ju; Choi, Sae Byeol; Park, Young Nyun; Choi, Jin Sub; Lee, Woo Jung; Kim, Kyung Sik
- Issue Date
- 5월-2011
- Publisher
- WILEY
- Keywords
- Hepatocellular carcinoma; Pregnancy
- Citation
- JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, v.18, no.3, pp.422 - 431
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
- Volume
- 18
- Number
- 3
- Start Page
- 422
- End Page
- 431
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112494
- DOI
- 10.1007/s00534-010-0345-6
- ISSN
- 1868-6974
- Abstract
- Hepatocellular carcinoma (HCC) during pregnancy is a very rare condition and is believed to have a worse prognosis than HCC in non-pregnant women. We evaluated the prognosis and the diagnostic and therapeutic strategies for HCC in pregnant women. We retrospectively analyzed 4 cases in our hospital and 44 cases described in the medical literature since 1957; we also compared the cases reported before 1995 and those reported during/after 1995. The overall 6-month and 1-, 2-, and 3-year survival rates in the patients reported in the literature were 50, 29.5, 18.2, and 13.6%, respectively (n = 44). The mean ages at diagnosis before and during/after 1995 were 31.4 +/- A 7.2 and 28.9 +/- A 4.4 years, respectively (P = 0.113). The following characteristics were significantly more common in the later group: fewer pregnancies; the absence of advanced signs or symptoms; receipt of therapy; tendency to undergo surgery; and higher 6-month and 1-, 2-, and 3-year survival rates. The median survivals of the groups before and during/after 1995 were 18 and 25.5 months, respectively (P < 0.001). The morbidity and mortality of HCC during pregnancy has improved over time, as diagnoses have tended to be made earlier and patients have tended to receive surgical and other treatments.
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