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RASSF1A suppresses the activated K-Ras-induced oxidative DNA damage
- Authors
- Park, Seon Ho; Kim, Jung Jin; Chung, Jin Sil; Lee, So Ra; Lee, Gi Young; Kim, Hyung Jung; Do Yoo, Young
- Issue Date
- 29-Apr-2011
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- K-Ras; RASSF1A; ROS; DNA damage
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.408, no.1, pp.149 - 153
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 408
- Number
- 1
- Start Page
- 149
- End Page
- 153
- ISSN
- 0006-291X
- Abstract
- The mutant K-Ras elevates intracellular reactive oxygen species (ROS) levels and leads to oxidative DNA damage, resulting in malignant cell transformation. Ras association domain family 1 isoform A (RASSF1A) is known to play a role as a Ras effector. However, the suppressive effect of RASSF1A on K-RasV12-induced ROS increase and DNA damage has not been identified. Here, we show that RASSF1A blocks K-RasV12-triggered ROS production. RASSF1A expression also inhibits oxidative DNA damage and chromosomal damage. From the results obtained in this study, we suggest that RASSF1A regulates the cellular ROS levels enhanced by the Ras signaling pathway, and that it may function as a tumor suppressor by suppressing DNA damage caused by activated Ras. (C) 2011 Elsevier Inc. All rights reserved.
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Collections - Graduate School > Department of Medicine > 1. Journal Articles
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Related Researcher
- Yoo, Young Do
- College of Medicine (Department of Medical Science)