Improved Endothelial Function in Patients with Atrial Fibrillation through Maintenance of Sinus Rhythm by Successful Catheter Ablation
- Authors
- Shin, Seung Yong; Na, Jin Oh; Lim, Hong Euy; Choi, Cheol Ung; Choi, Jong Il; Kim, Seong Hwan; Kim, Eung Ju; Park, Sang Weon; Rha, Seung-Woon; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo; Kim, Young-Hoon
- Issue Date
- 4월-2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- atrial fibrillation; catheter ablation; C-reactive protein; endothelial function; inflammation
- Citation
- JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, v.22, no.4, pp.376 - 382
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- Volume
- 22
- Number
- 4
- Start Page
- 376
- End Page
- 382
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112710
- DOI
- 10.1111/j.1540-8167.2010.01919.x
- ISSN
- 1045-3873
- Abstract
- Methods: This study prospectively enrolled 80 subjects who underwent CA for AF (paroxysmal AF = 61, persistent AF = 19). Eighty subjects with no history of AF were enrolled as controls, all of whom were matched by age, gender, body mass index, and atherosclerotic risk factor distribution. Brachial artery flow-mediated dilatation (FMD) was measured at baseline, and at 1 month and 6 months post CA in AF subjects who remained in SR. Among controls, FMD was measured at baseline and at 6 months. We used high sensitivity C-reactive protein (hs-CRP), interleukin-6, soluble E- or P-selectin, and endothelin-1 as biomarker indices for inflammation and/or ED. Results: Compared with controls, AF subjects had lower FMD at baseline (FMDbaseline, P < 0.001). After successful CA, FMD was significantly improved at 1 month and 6 months, nearly approaching control levels. A multivariate analysis revealed that FMDbaseline, hs-CRP, and left atrial volume (LAV) were independent predictors for arrhythmia recurrence after CA. Other biomarkers were not related to rhythm outcome. Conclusion: AF subjects have significantly impaired FMD, which can be reversed through maintenance of SR by successful CA. FMDbaseline, hs-CRP, and LAV are important predictors for AF recurrence after CA. (J Cardiovasc Electrophysiol, Vol. 22, pp. 376-382).
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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