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Fluorescence Probes for Tyrosine Dephosphorylation Based on Coumarin-Proline Conjugates
- Issue Date
- 5-3월-2011
- Publisher
- CHEMICAL SOC JAPAN
- Citation
- CHEMISTRY LETTERS, v.40, no.3, pp.290 - 291
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMISTRY LETTERS
- Volume
- 40
- Number
- 3
- Start Page
- 290
- End Page
- 291
- ISSN
- 0366-7022
- Abstract
- Proline-substituted coumarin compounds were prepared and used as environment-sensitive fluorescence probes. Phosphorylation and dephosphorylation of tyrosine derivatives labeled with the coumarin proline conjugate induced marked changes in fluorescence intensity allowing phosphatase activity to be monitored.
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