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Phorbasones A and B Sesterterpenoids Isolated from the Marine Sponge Phorbas sp and Induction of Osteoblast Differentiation
- Issue Date
- 4-3월-2011
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.13, no.5, pp.884 - 887
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC LETTERS
- Volume
- 13
- Number
- 5
- Start Page
- 884
- End Page
- 887
- ISSN
- 1523-7060
- Abstract
- Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.
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