Serum Adipocyte Fatty Acid-Binding Protein Is Associated Independently with Vascular Inflammation: Analysis with F-18-Fluorodeoxyglucose Positron Emission Tomography
DC Field | Value | Language |
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dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Kim, Sungeun | - |
dc.contributor.author | Park, Man Sik | - |
dc.contributor.author | Choi, Hae Yoon | - |
dc.contributor.author | Yang, Sae Jeong | - |
dc.contributor.author | Seo, Ji A. | - |
dc.contributor.author | Kim, Sin Gon | - |
dc.contributor.author | Kim, Nan Hee | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.contributor.author | Choi, Dong Seop | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.date.accessioned | 2021-09-07T14:36:46Z | - |
dc.date.available | 2021-09-07T14:36:46Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/112957 | - |
dc.description.abstract | Context: The inflammatory status of atherosclerotic lesions is a major factor triggering acute cardiovascular events. Growing evidence has shown that adipocyte fatty acid-binding protein (A-FABP) has an important role in the development of atherosclerosis. Objective: The objective of the study was to determine the association between circulating A-FABP levels with vascular inflammation as measured using [F-18]-fluorodeoxyglucose (FDG) positron emission tomography (PET), which is a novel imaging technique for noninvasive measurement of atherosclerotic inflammation. Design: This was a cross-sectional study. Participants: Eighty-seven men without previously diagnosed cardiovascular disease or diabetes participated in the study. Main Outcome Measure: We measured the serum A-FABP, adiponectin, and leptin levels as well as other cardiovascular risk factors. Vascular inflammation in the carotid arterial wall, as indicated by the target to background ratio (TBR), was analyzed using FDG-PET. Results: The circulating A-FABP and leptin levels had positive correlations with maximum TBR values (r = 0.38, P < 0.001; and r = 0.28, P = 0.010, respectively), where as the adiponectin levels had a negative correlation (r = -0.31, P = 0.004). The maximum TBR levels exhibited an additive linear increment according to the rise in tertiles of the A-FABP levels in subjects with and without metabolic syndrome. Multiple regression analysis showed that serum A-FABP levels were independently associated with maximum TBR after adjustment for other cardiovascular risk factors (P = 0.006). Conclusions: Circulating A-FABP, adiponectin, and leptin levels were shown to be associated with vascular inflammation, as measured using FDG-PET. Specifically, the A-FABP level was an independent risk factor for vascular inflammation in Korean men without cardiovascular disease or diabetes. (J Clin Endocrinol Metab 96: E488-E492, 2011) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ENDOCRINE SOC | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | PLAQUE INFLAMMATION | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | BIOMARKER | - |
dc.subject | OBESITY | - |
dc.subject | AP2 | - |
dc.title | Serum Adipocyte Fatty Acid-Binding Protein Is Associated Independently with Vascular Inflammation: Analysis with F-18-Fluorodeoxyglucose Positron Emission Tomography | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sungeun | - |
dc.contributor.affiliatedAuthor | Seo, Ji A. | - |
dc.contributor.affiliatedAuthor | Kim, Sin Gon | - |
dc.contributor.affiliatedAuthor | Kim, Nan Hee | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Dong Seop | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.identifier.doi | 10.1210/jc.2010-1473 | - |
dc.identifier.scopusid | 2-s2.0-79952291504 | - |
dc.identifier.wosid | 000288020600009 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.96, no.3, pp.E488 - E492 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.citation.title | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.citation.volume | 96 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | E488 | - |
dc.citation.endPage | E492 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | PLAQUE INFLAMMATION | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | AP2 | - |
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