Serum Adipocyte Fatty Acid-Binding Protein Is Associated Independently with Vascular Inflammation: Analysis with F-18-Fluorodeoxyglucose Positron Emission Tomography
- Authors
- Yoo, Hye Jin; Kim, Sungeun; Park, Man Sik; Choi, Hae Yoon; Yang, Sae Jeong; Seo, Ji A.; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei Hyun; Choi, Dong Seop; Choi, Kyung Mook
- Issue Date
- 3월-2011
- Publisher
- ENDOCRINE SOC
- Citation
- JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.96, no.3, pp.E488 - E492
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Volume
- 96
- Number
- 3
- Start Page
- E488
- End Page
- E492
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112957
- DOI
- 10.1210/jc.2010-1473
- ISSN
- 0021-972X
- Abstract
- Context: The inflammatory status of atherosclerotic lesions is a major factor triggering acute cardiovascular events. Growing evidence has shown that adipocyte fatty acid-binding protein (A-FABP) has an important role in the development of atherosclerosis. Objective: The objective of the study was to determine the association between circulating A-FABP levels with vascular inflammation as measured using [F-18]-fluorodeoxyglucose (FDG) positron emission tomography (PET), which is a novel imaging technique for noninvasive measurement of atherosclerotic inflammation. Design: This was a cross-sectional study. Participants: Eighty-seven men without previously diagnosed cardiovascular disease or diabetes participated in the study. Main Outcome Measure: We measured the serum A-FABP, adiponectin, and leptin levels as well as other cardiovascular risk factors. Vascular inflammation in the carotid arterial wall, as indicated by the target to background ratio (TBR), was analyzed using FDG-PET. Results: The circulating A-FABP and leptin levels had positive correlations with maximum TBR values (r = 0.38, P < 0.001; and r = 0.28, P = 0.010, respectively), where as the adiponectin levels had a negative correlation (r = -0.31, P = 0.004). The maximum TBR levels exhibited an additive linear increment according to the rise in tertiles of the A-FABP levels in subjects with and without metabolic syndrome. Multiple regression analysis showed that serum A-FABP levels were independently associated with maximum TBR after adjustment for other cardiovascular risk factors (P = 0.006). Conclusions: Circulating A-FABP, adiponectin, and leptin levels were shown to be associated with vascular inflammation, as measured using FDG-PET. Specifically, the A-FABP level was an independent risk factor for vascular inflammation in Korean men without cardiovascular disease or diabetes. (J Clin Endocrinol Metab 96: E488-E492, 2011)
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