Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments
- Authors
- Zervantonakis, Ioannis K.; Kothapalli, Chandrasekhar R.; Chung, Seok; Sudo, Ryo; Kamm, Roger D.
- Issue Date
- 3월-2011
- Publisher
- AMER INST PHYSICS
- Citation
- BIOMICROFLUIDICS, v.5, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMICROFLUIDICS
- Volume
- 5
- Number
- 1
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112971
- DOI
- 10.1063/1.3553237
- ISSN
- 1932-1058
- Abstract
- Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length-and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3553237]
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Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
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