Capecitabine monotherapy as salvage treatment after failure of chemotherapy containing oxaliplatin and irinotecan in patients with metastatic colorectal cancer
- Authors
- Kim, Seung T.; Choi, Yoon J.; Park, Kyong H.; Oh, Sang C.; Seo, Jae H.; Shin, Sang W.; Kim, Jun S.; Kim, Yeul H.
- Issue Date
- 3월-2011
- Publisher
- WILEY
- Keywords
- capecitabine; FOLFIRI; FOLFOX
- Citation
- ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, v.7, no.1, pp.82 - 87
- Indexed
- SCIE
SCOPUS
- Journal Title
- ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
- Volume
- 7
- Number
- 1
- Start Page
- 82
- End Page
- 87
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112980
- DOI
- 10.1111/j.1743-7563.2010.01363.x
- ISSN
- 1743-7555
- Abstract
- Aim: There has been limited data on capecitabine monotherapy in metastatic colorectal cancer (CRC) patients who were previously treated with both oxaliplatin/5-fluorouracil(FU)/leucovorin (FOLFOX) and irinotecan/5-FU/leucovorin (FOLFIRI). Methods: We analyzed 20 patients between August 2002 and March 2008 with metastatic CRC who had been treated with capecitabine monotherapy after the failure of FOLFOX and FOLFIRI. Results: Overall, one partial response was observed (overall response rate, 5%) and stable disease was observed in 11 patients (55.0%). The disease control rate was 60.0%. The median progression-free survival (PFS) was 2.3 months (95% CI 1.9-2.7) and the median overall survival (OS) was 5.3 months (95% CI 4.6-6.0). Patients without ascites had longer PFS than those with ascites (P = 0.02). Patients with more than three metastatic sites had poorer OS than those with less than two (P = 0.01). Grade 3 or 4 non-hematological toxicities included hand-foot syndrome in one patient. There were no grade 3 or 4 hematological toxicities or treatment-related deaths. Conclusion: The capecitabine monotherapy had a moderate disease control rate and a tolerable toxicity profile as third-line or fourth-line treatment for metastatic CRC patients who were refractory to standard chemotherapy with no further treatment options.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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