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Molecular imaging with terahertz waves

Authors
Oh, Seung JaeChoi, JihyeMaeng, InheePark, Jae YeonLee, KwangyeolHuh, Yong-MinSuh, Jin-SuckHaam, SeungjooSon, Joo-Hiuk
Issue Date
28-2월-2011
Publisher
OPTICAL SOC AMER
Citation
OPTICS EXPRESS, v.19, no.5, pp.4009 - 4016
Indexed
SCIE
SCOPUS
Journal Title
OPTICS EXPRESS
Volume
19
Number
5
Start Page
4009
End Page
4016
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/113036
DOI
10.1364/OE.19.004009
ISSN
1094-4087
Abstract
We demonstrate a highly sensitive THz molecular imaging (TMI) technique involving differential modulation of surface plasmons induced on nanoparticles and obtain target specific in vivo images of cancers. This technique can detect quantities of gold nanoparticles as small as 15 mu M in vivo. A comparison of TMI images with near infrared absorption images shows the superior sensitivity of TMI. Furthermore, the quantification property of TMI is excellent, being linearly proportional to the concentration of nanoparticles. The target specificity issue is also addressed at the ex vivo and cell levels. The high thermal sensitivity of TMI can help extend photonic-based photothermal molecular imaging researches from the in vitro level to the in vivo level. The TMI technique can be used for monitoring drug delivery processes and for early cancer diagnosis. (C) 2011 Optical Society of America
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