Synthesis of C-6-Epimer Derivatives of Diacetoxy Acetal Derivative of Santonin and their Inducing Effects on HL-60 Leukemia Cell Differentiation
DC Field | Value | Language |
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dc.contributor.author | Kweon, Sin Ho | - |
dc.contributor.author | Kim, Keun Tae | - |
dc.contributor.author | Hong, Joon Hee | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Choi, Bo Gil | - |
dc.date.accessioned | 2021-09-07T15:26:54Z | - |
dc.date.available | 2021-09-07T15:26:54Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113102 | - |
dc.description.abstract | Induction of differentiation is a new and promising approach to leukemia therapy, well illustrated by the treatment of acute promyelocytic leukemia with 1,25-dihydroxyvitamin D-3 [1,25-(OH)(2)D-3] or all-trans retinoic acid (ATRA). Using combination of either 1,25-(OH)(2)D-3 or ATRA and chemotherapy, adverse effects 1,25-(OH)(2)D-3 or ATRA such as hypercalcemic effects have decreased, and long-term survival has improved. In a previous study, we demonstrated that santonin could be chemically modified into a diacetoxy acetal derivative of santonin with strong differentiation-inducing activity. In this study, we further synthesized C-6-epimer derivatives of diacetoxy acetal derivative of santonin and tested their effects on HL-60 cell differentiation. Some of the C-6-epimer derivatives themselves induced increases in cell differentiation. Especially, (11S)-3,3-(ethylenedioxy) eudesmano-13-ol-6 beta-acetate (7) was demonstrated to induce differentiation with larger than 80% of the cells attaining a differentiated phenotype. Importantly, 7 strongly enhanced differentiation of HL-60 cells in a dose-dependent manner when combined with either low doses of 1,25-(OH)(2)D-3 or ATRA. The ability to enhance the differentiation potential of 1,25-(OH)(2)D-3 or ATRA by 7 may improve outcomes in the therapy of acute promyelocytic leukemia. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.subject | ACUTE PROMYELOCYTIC LEUKEMIA | - |
dc.subject | TRANS-RETINOIC ACID | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | 1,25-DIHYDROXYVITAMIN D-3 | - |
dc.subject | MYELOID-LEUKEMIA | - |
dc.subject | INDUCTION | - |
dc.subject | ENHANCEMENT | - |
dc.title | Synthesis of C-6-Epimer Derivatives of Diacetoxy Acetal Derivative of Santonin and their Inducing Effects on HL-60 Leukemia Cell Differentiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1007/s12272-011-0202-4 | - |
dc.identifier.scopusid | 2-s2.0-79953297756 | - |
dc.identifier.wosid | 000287949000003 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.34, no.2, pp.191 - 198 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 191 | - |
dc.citation.endPage | 198 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001526993 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ACUTE PROMYELOCYTIC LEUKEMIA | - |
dc.subject.keywordPlus | TRANS-RETINOIC ACID | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | 1,25-DIHYDROXYVITAMIN D-3 | - |
dc.subject.keywordPlus | MYELOID-LEUKEMIA | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordAuthor | DAAS | - |
dc.subject.keywordAuthor | 6-Epimer | - |
dc.subject.keywordAuthor | Differentiation | - |
dc.subject.keywordAuthor | Leukemia | - |
dc.subject.keywordAuthor | 1,25-dihydroxyvitamin D-3 | - |
dc.subject.keywordAuthor | All-trans retinoic acid | - |
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