Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: Insights from the Korea Acute Myocardial Infarction Registry
- Authors
- Choi, Cheol Ung; Rha, Seung-Woon; Oh, Dong Joo; Poddar, Kanhaiya L.; Na, Jin Oh; Kim, Jin Won; Lim, Hong Euy; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Hong, Taek Jong; Park, Jong-Seon; Kim, Young Jo; Hur, Seung Ho; Seong, In Whan; Chae, Jei Keon; Cho, Myeong Chan; Bae, Jang Ho; Choi, Dong Hoon; Jang, Yang Soo; Chae, In Ho; Kim, Hyo Soo; Kim, Chong Jin; Yoon, Jung Han; Ahn, Tae Hoon; Tahk, Seung-Jea; Chung, Wook Sung; Seung, Ki Bae; Chae, Shung Chall; Park, Seung Jung; Ahn, Young Keun; Jeong, Myung Ho
- Issue Date
- Feb-2011
- Publisher
- MOSBY-ELSEVIER
- Citation
- AMERICAN HEART JOURNAL, v.161, no.2, pp.373 - U586
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN HEART JOURNAL
- Volume
- 161
- Number
- 2
- Start Page
- 373
- End Page
- U586
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/113125
- DOI
- 10.1016/j.ahj.2010.10.031
- ISSN
- 0002-8703
- Abstract
- Background The optimal loading dose of clopidogrel in Asian patients with ST-segment elevation myocardial infarction (STEMI) has not been fully investigated. We compared bleeding, vascular complications, and midterm outcomes of a 300-mg versus a 600-mg loading dose of clopidogrel in a large series of Korean patients with STEMI undergoing primary percutaneous coronary intervention (PCI). Methods A total of 2,664 STEMI patients (age 61.96 +/- 11.91 years, men 70.4%) who underwent primary PCI were enrolled in this study. The patients were divided into a standard loading dose group (300 mg; n = 1,447 patients) and a high loading dose group (600 mg; n = 1,217 patients). Bleeding and vascular complications, and in-hospital and clinical outcomes up to 12 months were compared between the 2 groups. Results In-hospital bleeding and vascular complications were similar between the 2 groups. There were no differences in bleeding and vascular complications and in 1- and 12-month clinical outcomes, including mortality, myocardial infarction, repeated PCI, and major adverse cardiac events, between the 2 groups. These findings were consistent even after the propensity score-matched analysis. Conclusions The standard loading dose of clopidogrel may be as safe and similarly effective as the high loading dose in Asian STEMI patients undergoing primary PCI. (Am Heart J 2011;161:373-382.e3.)
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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