Genetic Polymorphism of Plasmodium vivax msp1p, a Paralog of Merozoite Surface Protein 1, from Worldwide Isolates
DC Field | Value | Language |
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dc.contributor.author | Wang, Yue | - |
dc.contributor.author | Kaneko, Osamu | - |
dc.contributor.author | Sattabongkot, Jetsumon | - |
dc.contributor.author | Chen, Jun-Hu | - |
dc.contributor.author | Lu, Feng | - |
dc.contributor.author | Chai, Jong-Yil | - |
dc.contributor.author | Takeo, Satoru | - |
dc.contributor.author | Tsuboi, Takafumi | - |
dc.contributor.author | Ayala, Francisco J. | - |
dc.contributor.author | Chen, Yong | - |
dc.contributor.author | Lim, Chae Seung | - |
dc.contributor.author | Han, Eun-Taek | - |
dc.date.accessioned | 2021-09-07T15:36:05Z | - |
dc.date.available | 2021-09-07T15:36:05Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.issn | 0002-9637 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113148 | - |
dc.description.abstract | Plasmodium vivax msp1p, a paralog of the candidate vaccine antigen P vivax merozoite surface protein I, possesses a signal peptide at its N-terminus and two epidermal growth factor like domains at its C-terminus with a glycosylphosphatidylinositol attachment site. The msp1p gene locus may have originated by a duplication of the msp1 gene locus in a common ancestor of the analyzed Plasmodium species and lost from P yoelii, P berghei, and P falciparum during their evolutionary history. Full-length sequences of the msp1 p gene were generally highly conserved; they had a few amino acid substitutions, one highly polymorphic E/Q-rich region, and a single-to-triple hepta-peptide repeat motif. Twenty-one distinguishable allelic types (A1-A21) of the E/Q-rich region were identified from worldwide isolates. Among them, four types were detected in isolates from South Korea. The length polymorphism of the E/Q-rich region might be useful as a genetic marker for population structure studies in malaria-endemic areas. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC TROP MED & HYGIENE | - |
dc.subject | HUMAN MALARIA PARASITE | - |
dc.subject | LOW-COMPLEXITY REGIONS | - |
dc.subject | DIVERSITY | - |
dc.subject | FALCIPARUM | - |
dc.subject | POPULATIONS | - |
dc.subject | SEARCH | - |
dc.title | Genetic Polymorphism of Plasmodium vivax msp1p, a Paralog of Merozoite Surface Protein 1, from Worldwide Isolates | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Chae Seung | - |
dc.identifier.doi | 10.4269/ajtmh.2011.10-0432 | - |
dc.identifier.scopusid | 2-s2.0-79952637836 | - |
dc.identifier.wosid | 000287003900020 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.84, no.2, pp.292 - 297 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | - |
dc.citation.title | AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | - |
dc.citation.volume | 84 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 292 | - |
dc.citation.endPage | 297 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalResearchArea | Tropical Medicine | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Tropical Medicine | - |
dc.subject.keywordPlus | HUMAN MALARIA PARASITE | - |
dc.subject.keywordPlus | LOW-COMPLEXITY REGIONS | - |
dc.subject.keywordPlus | DIVERSITY | - |
dc.subject.keywordPlus | FALCIPARUM | - |
dc.subject.keywordPlus | POPULATIONS | - |
dc.subject.keywordPlus | SEARCH | - |
dc.subject.keywordAuthor | P.vivax map1 | - |
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