Genetic Polymorphism of Plasmodium vivax msp1p, a Paralog of Merozoite Surface Protein 1, from Worldwide Isolates
- Authors
- Wang, Yue; Kaneko, Osamu; Sattabongkot, Jetsumon; Chen, Jun-Hu; Lu, Feng; Chai, Jong-Yil; Takeo, Satoru; Tsuboi, Takafumi; Ayala, Francisco J.; Chen, Yong; Lim, Chae Seung; Han, Eun-Taek
- Issue Date
- 2월-2011
- Publisher
- AMER SOC TROP MED & HYGIENE
- Keywords
- P.vivax map1
- Citation
- AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.84, no.2, pp.292 - 297
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Volume
- 84
- Number
- 2
- Start Page
- 292
- End Page
- 297
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/113148
- DOI
- 10.4269/ajtmh.2011.10-0432
- ISSN
- 0002-9637
- Abstract
- Plasmodium vivax msp1p, a paralog of the candidate vaccine antigen P vivax merozoite surface protein I, possesses a signal peptide at its N-terminus and two epidermal growth factor like domains at its C-terminus with a glycosylphosphatidylinositol attachment site. The msp1p gene locus may have originated by a duplication of the msp1 gene locus in a common ancestor of the analyzed Plasmodium species and lost from P yoelii, P berghei, and P falciparum during their evolutionary history. Full-length sequences of the msp1 p gene were generally highly conserved; they had a few amino acid substitutions, one highly polymorphic E/Q-rich region, and a single-to-triple hepta-peptide repeat motif. Twenty-one distinguishable allelic types (A1-A21) of the E/Q-rich region were identified from worldwide isolates. Among them, four types were detected in isolates from South Korea. The length polymorphism of the E/Q-rich region might be useful as a genetic marker for population structure studies in malaria-endemic areas.
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