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Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure

Authors
Soon, Young-MiShin, Kwan-HaKoh, Young-HagLee, Jong-HoonChoi, Won-YoungKim, Hyoun-Ee
Issue Date
1월-2011
Publisher
ELSEVIER SCI LTD
Keywords
Suspensions; Porosity; Mechanical properties; Apatite; Biomedical applications
Citation
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, v.31, no.1-2, pp.13 - 18
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
Volume
31
Number
1-2
Start Page
13
End Page
18
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/113331
DOI
10.1016/j.jeurceramsoc.2010.09.008
ISSN
0955-2219
Abstract
A novel type of porous hydroxyapatite (HA) scaffolds with a functionally graded core/shell structure was fabricated by freeze casting HA/camphene slurries with various HA contents into fugitive molds containing a graphite template with three dimensionally interconnected pores for the creation of a highly porous core All the fabricated samples had functionally graded core/shell structures with 3-D periodic pore networks in a core surrounded by a relatively dense shell The overall porosity of the sample decreased from 60 to 38 vol% with increasing HA content in the HA/camphene slurry from 20 to 36 vol% due to a decrease in porosity in both the core and shell regions In addition, the compressive strength was improved remarkably from 12 +/- 11 to 32 +/- 3 0 MPa The in vitro cell test using a pre-osteoblast cell line showed that the samples had good biocompatibility (C) 2010 Elsevier Ltd All rights reserved
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