Grape Seed Extract Regulates Androgen Receptor-Mediated Transcription in Prostate Cancer Cells Through Potent Anti-Histone Acetyltransferase Activity
DC Field | Value | Language |
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dc.contributor.author | Park, Si Yong | - |
dc.contributor.author | Lee, Yoo-Hyun | - |
dc.contributor.author | Choi, Kyung-Chul | - |
dc.contributor.author | Seong, Ah-Reum | - |
dc.contributor.author | Choi, Hyo-Kyoung | - |
dc.contributor.author | Lee, Ok-Hee | - |
dc.contributor.author | Hwang, Han-Joon | - |
dc.contributor.author | Yoon, Ho-Geun | - |
dc.date.accessioned | 2021-09-07T16:33:10Z | - |
dc.date.available | 2021-09-07T16:33:10Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113371 | - |
dc.description.abstract | Histone acetylation, which is regulated by histone acetyltransferases (HATs) and deacetylases, is an epigenetic mechanism that influences eukaryotic transcription. Significant changes in histone acetylation are associated with cancer; therefore, manipulating the acetylation status of key gene targets is likely crucial for effective cancer therapy. Grape seed extract (GSE) has a known protective effect against prostate cancer. Here, we showed that GSE significantly inhibited HAT activity by 30-80% in vitro (P < .05). Furthermore, we demonstrated significant repression of androgen receptor (AR)-mediated transcription by GSE in prostate cancer cells by measuring luciferase activity using a pGL3-PSA construct bearing the AR element in the human prostate cancer cell line LNCaP (P < .05). GSE treatment also decreased the mRNA level of the AR-regulated genes PSA and NKX 3.1. Finally, GSE inhibited growth of LNCaP cells. These results indicate that GSE potently inhibits HAT, leading to decreased AR-mediated transcription and cancer cell growth, and implicate GSE as a novel candidate for therapeutic activity against prostate cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | CHROMATIN TRANSCRIPTION | - |
dc.subject | APOPTOSIS | - |
dc.subject | ACETYLATION | - |
dc.subject | GROWTH | - |
dc.subject | INHIBITOR | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.subject | INDUCTION | - |
dc.subject | REPRESSES | - |
dc.subject | GARCINOL | - |
dc.title | Grape Seed Extract Regulates Androgen Receptor-Mediated Transcription in Prostate Cancer Cells Through Potent Anti-Histone Acetyltransferase Activity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Han-Joon | - |
dc.identifier.doi | 10.1089/jmf.2010.1264 | - |
dc.identifier.scopusid | 2-s2.0-79952085774 | - |
dc.identifier.wosid | 000286385100003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.14, no.1-2, pp.9 - 16 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 9 | - |
dc.citation.endPage | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CHROMATIN TRANSCRIPTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ACETYLATION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | REPRESSES | - |
dc.subject.keywordPlus | GARCINOL | - |
dc.subject.keywordAuthor | androgen receptor | - |
dc.subject.keywordAuthor | grape seed extract | - |
dc.subject.keywordAuthor | histone acetyltransferase | - |
dc.subject.keywordAuthor | prostate cancer | - |
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