Lateral Displacement and Conformation of DNA Chains in Abrupt 90 degrees Microbends
- Authors
- Lee, Jeong Yong; Jung, Hyun Wook; Hyun, Jae Chun; Chun, Myung-Suk
- Issue Date
- 1월-2011
- Publisher
- KOREAN PHYSICAL SOC
- Keywords
- lambda-DNA molecule; Brownian dynamics; Microbends; Migration; Conformation
- Citation
- JOURNAL OF THE KOREAN PHYSICAL SOCIETY, v.58, no.1, pp.125 - 131
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF THE KOREAN PHYSICAL SOCIETY
- Volume
- 58
- Number
- 1
- Start Page
- 125
- End Page
- 131
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/113389
- DOI
- 10.3938/jkps.58.125
- ISSN
- 0374-4884
- Abstract
- The migration and conformation of a single lambda-DNA chain in a microchannel with a 90 degrees bend have been investigated using the hybrid numerical scheme of Brownian dynamics (BD) simulations and a CFD (computational fluid dynamics) solver, Flow-3D. A significant displacement of the single DNA chain was found after it had passed through the microbend and depended on its initial location. The lambda-DNA chain initially positioned near the inner (or outer) wall migrated farther toward the inner (or outer) wall after passage through the bend. This is ascribed by the hydrodynamic features of the bulk flow field in the bend region. The relationship between an extension of the single chain and the flow characteristics was elucidated by changing the effective shear rate and the channel width.
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Collections - College of Engineering > Department of Chemical and Biological Engineering > 1. Journal Articles
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