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생약 조성물, DTS20의 알코올 분해 및 항염증 효과Effect of Herbal Composition, DTS20 on Alcohol Degradation and Anti-inflammatory Activity

Other Titles
Effect of Herbal Composition, DTS20 on Alcohol Degradation and Anti-inflammatory Activity
Authors
윤택준조선영이수정김은영신광순서형주
Issue Date
2011
Publisher
한국생물공학회
Keywords
Herbal extracts; alcohol; inflammation; cytokine; NO
Citation
KSBB Journal, v.26, no.5, pp.433 - 438
Indexed
KCI
Journal Title
KSBB Journal
Volume
26
Number
5
Start Page
433
End Page
438
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/114090
ISSN
1225-7117
Abstract
These studies were conducted to investigate the alcohol degradation effects of the extract of herbal composition (DTS20) containing Viscum album L., Lycium chinense L.,Inonotus obliquus and Acanthopanax senticosus H., on the alcohol administered mice. To investigate anti-hangover effect,alcohol and alcohol dehydrogensae (ADH) concentration of blood were measured after oral administration of ethanol. The administration of DTS20 (200-500 mg/kg) had beneficial actions toward alcohol degradation in acute alcohol treated mice model. The oral administration of DTS20 showed decreased gastric mucous membrane damage produced in ethanol treated mice. In addition, intraperitoneal administration of DTS20 showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. DTS20 also reduced the concentration of nitric oxide (NO), tumor necrosis factor (TNF)-α in macrophages that were activated by LPS. These results demonstrate that DTS20 possesses potential to stimulate the alcohol degradation and inhibit the inflammatory effects in mice.
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보건과학대학 (바이오시스템의과학부)
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