우울장애 환자에서 항우울제 치료가 삶의 질에 미치는 영향

Abstract

Objectives：Depressive disorders are severe or persistent enough to interfere with daily functionings and quality of life(QOL). This study was aimed to evaluate the effect of antidepressant treatment on QOL in patients with depressive disorders. Methods：Three hundred seventeen patients with depressive disorders were enrolled from a cohort, which was established at one clinical research center for depression. Patients were divided into remission and non-remission groups, according to the scores of Korean version of Hamilton Depression Rating Scale(K-HDRS). The Korean version of World Health Organization Quality of Life Scale Abbreviated Version(K-WHOQOL-BREF) was used for the assessment of QOL. Results：No significant differences between two groups existed in sociodemographic data and types of antidepressants taken. Regardless of groups, depressive symptoms were negatively correlated with all four domains of the WHOQOL-BREF and significant improvements were also observed in its four domains after 6 months of antidepressant treatment. These improvements were more pronounced in remission group than in non-remission groups. Conclusion：This study confirmed that subjective improvement in QOL can be achieved by antidepressant treatment whether patients with depressive disorders were remitted or not after 6 months of antidepressant treatment.