Composite Pheochromocytoma or Paraganglioma of Adrenal Gland: A Case Report with Immunohistochemical Studies and Electron Microscopic Examination
- Authors
- Chang, Hyeyoon; Jeong, Hoiseon; Kim, Younghye; Park, Sung-Hye; Kim, Aeree
- Issue Date
- 2011
- Publisher
- KOREAN SOCIETY PATHOLOGISTS
- Keywords
- Composite pheochromocytoma and ganglioneuroma; Pheochromocytoma; Paraganglioma; Adrenal glands
- Citation
- KOREAN JOURNAL OF PATHOLOGY, v.45, no.3, pp.306 - 310
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF PATHOLOGY
- Volume
- 45
- Number
- 3
- Start Page
- 306
- End Page
- 310
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115026
- DOI
- 10.4132/KoreanJPathol.2011.45.3.306
- ISSN
- 1738-1843
- Abstract
- Composite pheochromocytoma or paraganglioma of the adrenal gland is a well-recognized, yet extremely rare tumor with only one case reported in Korea. We report a case of incidentally found composite pheochromocytoma and ganglioneuroma of the adrenal gland in a 44-year-old female composed of intermingled components of pheochromocytom, ganglioneuroma, and cells with intermediate features. On immunohistochemical staining, the pheochromocytoma component was positive for synaptophysin and chromogranin, but negative for S-100 protein. Staining for the S-100 protein revealed sustentacular cells which formed a peripheral coat around the "Zellballen" and Schwann cells. The Fontana-Masson stain defined neuromelanin granules of ganglion cells and the ganglion cells expressed neural markers such as neurofilament proteins. Ultrastructural findings revealed pheochromocytes with a round or ovoid nucleus and occasionally prominent nucleolus containing numerous adrenaline and noradrenaline granules.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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