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Can mean platelet volume predict coronary vasospasm?

Authors
Choi, Cheol UngSeo, Hong SeogKim, Yun KyungNa, Jin OhLim, Hong EuyKim, Jin WonKim, Eung JuRha, Seung-WoonPark, Chang GyuOh, Dong Joo
Issue Date
2011
Publisher
INFORMA HEALTHCARE
Keywords
Mean platelet volume; Ach-induced coronary vasospasm
Citation
PLATELETS, v.22, no.3, pp.173 - 178
Indexed
SCIE
SCOPUS
Journal Title
PLATELETS
Volume
22
Number
3
Start Page
173
End Page
178
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115033
DOI
10.3109/09537104.2010.538094
ISSN
0953-7104
Abstract
Mean platelet volume (MPV) is an index of platelet function that reflects platelet production rate and sensitivity to activation. The relationship between MPV and coronary vasospasm has not been previously studied. In this study, we aimed to evaluate this relationship. A total of 696 patients (age 55.20 +/-+/- 12.26, male 46.4%%, female 53.6%%) with typical or atypical angina who underwent diagnostic coronary angiography (CAG) and an acetylcholine (Ach)-provocation test were enrolled. Each patient was assigned to either an Ach-induced coronary vasospasm group (n == 183) or a control group (n == 513). We compared MPV between the two groups. MPV and the platelet count showed a negative correlation (r == --0.289, p < 0.001). MPV was higher in the Ach-induced coronary vasospasm group than in the control group (9.03 +/-+/- 1.37 fl and 8.69 +/-+/- 1.25 fl, respectively, p == 0.002). In multivariate analysis, MPV independently predicted Ach-induced coronary vasospasm (OR == 1.188, p == 0.018). This study identified high MPV as an independent risk factor for Ach-induced coronary vasospasm.</.
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