Separation of platelets from whole blood using standing surface acoustic waves in a microchannel
DC Field | Value | Language |
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dc.contributor.author | Nam, Jeonghun | - |
dc.contributor.author | Lim, Hyunjung | - |
dc.contributor.author | Kim, Dookon | - |
dc.contributor.author | Shin, Sehyun | - |
dc.date.accessioned | 2021-09-07T21:56:52Z | - |
dc.date.available | 2021-09-07T21:56:52Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1473-0197 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115048 | - |
dc.description.abstract | Platelet separation from blood is essential for biochemical analyses and clinical diagnosis. In this article, we propose a method to separate platelets from undiluted whole blood using standing surface acoustic waves (SSAWs) in a microfluidic device. A polydimethylsiloxane (PDMS) microfluidic channel was fabricated and integrated with interdigitated transducer (IDT) electrodes patterned on a piezoelectric substrate. To avoid shear-induced activation of platelets, the blood sample flow was hydrodynamically focused by introducing sheath flow from two side-inlets and pressure nodes were designed to locate at side walls. By means of flow cytometric analysis, the RBC clearance ratio from whole blood was found to be over 99% and the purity of platelets was close to 98%. Conclusively, the present technique using SSAWs can directly separate platelets from undiluted whole blood with higher purity than other methods. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | RICH PLASMA | - |
dc.subject | MECHANICS | - |
dc.subject | PARTICLES | - |
dc.title | Separation of platelets from whole blood using standing surface acoustic waves in a microchannel | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Sehyun | - |
dc.identifier.doi | 10.1039/c1lc20346k | - |
dc.identifier.scopusid | 2-s2.0-80052536944 | - |
dc.identifier.wosid | 000294503200022 | - |
dc.identifier.bibliographicCitation | LAB ON A CHIP, v.11, no.19, pp.3361 - 3364 | - |
dc.relation.isPartOf | LAB ON A CHIP | - |
dc.citation.title | LAB ON A CHIP | - |
dc.citation.volume | 11 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 3361 | - |
dc.citation.endPage | 3364 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Instruments & Instrumentation | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Instruments & Instrumentation | - |
dc.subject.keywordPlus | RICH PLASMA | - |
dc.subject.keywordPlus | MECHANICS | - |
dc.subject.keywordPlus | PARTICLES | - |
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