Evaluation of Plasmodium vivax ELISA for the blood screen
- Authors
- Nam, Myung-Hyun; Kim, Jang Su; Cho, Chi Hyun; Han, Eun Taek; Lee, Won Ja; Lee, Hee Kyung; An, Seong Soo A.; Lim, Chae Seung; Lee, Kap No
- Issue Date
- 12월-2010
- Publisher
- WILEY
- Keywords
- Plasmodium vivax; ELISA; antibody test; Republic of Korea
- Citation
- TROPICAL MEDICINE & INTERNATIONAL HEALTH, v.15, no.12, pp.1436 - 1441
- Indexed
- SCIE
SCOPUS
- Journal Title
- TROPICAL MEDICINE & INTERNATIONAL HEALTH
- Volume
- 15
- Number
- 12
- Start Page
- 1436
- End Page
- 1441
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115157
- DOI
- 10.1111/j.1365-3156.2010.02657.x
- ISSN
- 1360-2276
- Abstract
- Plasmodium virax malaria is the indigenous strain in the Republic of Korea (ROK). Plasmodium virax can be transmitted through the transfusions of various blood components, which became a severe problem with the safety of blood transfusions and blood-related products in ROK. We evaluated a P. vivax-specific enzyme-linked immunosorbent assay (Genedia Malaria Ab ELISA 2.0, Green Cross, ROK) with blood samples from four groups: 251 samples from P. vivax-infected patients, 39 samples from post-treatment patients upon follow-up, 200 samples from healthy volunteers and 421 samples from domestic travellers to and from high endemic areas of ROK. The positive cases from the ELBA test were confirmed by both Gierrisa microscopic and polymerase chain reaction methods. The clinical sensitivity and specificity of detecting P. vivax with ELISA test were 94.4% and 99.0%, respectively. Thirteen of 421 domestic travellers (3.0%) to endemic areas tested positive. The results indicate the effectiveness of detecting antibodies against P. vivax in blood with Genedia Malaria Ab ELISA 2.0 test in a large blood screen setting.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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