The Efficacy of Bone Morphogenetic Protein-2 Depends on Its Mode of Delivery
DC Field | Value | Language |
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dc.contributor.author | La, Wan-Geun | - |
dc.contributor.author | Kang, Sun-Woong | - |
dc.contributor.author | Yang, Hee Seok | - |
dc.contributor.author | Bhang, Suk Ho | - |
dc.contributor.author | Lee, Sun Hwa | - |
dc.contributor.author | Park, Jung-Ho | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2021-09-07T22:31:00Z | - |
dc.date.available | 2021-09-07T22:31:00Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0160-564X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115224 | - |
dc.description.abstract | Bone morphogenetic protein-2 (BMP-2) induces bone regeneration in a dose-dependent manner, with higher doses of BMP-2 inducing greater bone formation. Previously, we showed that long-term delivery of BMP-2 provides better ectopic bone formation than short-term delivery of an equivalent dose. In the present study, we investigated the efficacy of orthotopic bone formation over a range of BMP-2 doses, using different delivery modes. Heparin-conjugated poly(lactic-co-glycolic acid) nanospheres suspended in fibrin gel were used as a long-term delivery system, and fibrin gel was used as a short-term delivery system. Different doses of BMP-2 were delivered to mouse calvarial defects using either long-term or short-term delivery systems. Eight weeks after treatment, bone regeneration was evaluated by histomorphometry. For both delivery systems, bone regeneration increased as the BMP-2 dose increased up to 1 mu g and did not increase beyond this dose. Importantly, at BMP-2 doses higher than 1 mu g, long-term delivery resulted in much greater bone formation than short-term delivery. This study shows that long-term delivery of BMP-2 is more effective at enhancing orthotopic bone formation than short-term delivery over a range of doses. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | IN-VIVO | - |
dc.subject | SUSTAINED-RELEASE | - |
dc.subject | LONG-TERM | - |
dc.subject | REGENERATION | - |
dc.subject | SCAFFOLDS | - |
dc.subject | RHBMP-2 | - |
dc.subject | GROWTH | - |
dc.title | The Efficacy of Bone Morphogenetic Protein-2 Depends on Its Mode of Delivery | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jung-Ho | - |
dc.identifier.doi | 10.1111/j.1525-1594.2009.00988.x | - |
dc.identifier.scopusid | 2-s2.0-78650038240 | - |
dc.identifier.wosid | 000285302600013 | - |
dc.identifier.bibliographicCitation | ARTIFICIAL ORGANS, v.34, no.12, pp.1150 - 1153 | - |
dc.relation.isPartOf | ARTIFICIAL ORGANS | - |
dc.citation.title | ARTIFICIAL ORGANS | - |
dc.citation.volume | 34 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1150 | - |
dc.citation.endPage | 1153 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SUSTAINED-RELEASE | - |
dc.subject.keywordPlus | LONG-TERM | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | RHBMP-2 | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | BMP-2 delivery | - |
dc.subject.keywordAuthor | Bone formation | - |
dc.subject.keywordAuthor | Fibrin gel | - |
dc.subject.keywordAuthor | Heparin-conjugated poly(lactic-co-glycolic acid) nanosphere | - |
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