The Efficacy of Bone Morphogenetic Protein-2 Depends on Its Mode of Delivery
- Authors
- La, Wan-Geun; Kang, Sun-Woong; Yang, Hee Seok; Bhang, Suk Ho; Lee, Sun Hwa; Park, Jung-Ho; Kim, Byung-Soo
- Issue Date
- 12월-2010
- Publisher
- WILEY
- Keywords
- BMP-2 delivery; Bone formation; Fibrin gel; Heparin-conjugated poly(lactic-co-glycolic acid) nanosphere
- Citation
- ARTIFICIAL ORGANS, v.34, no.12, pp.1150 - 1153
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARTIFICIAL ORGANS
- Volume
- 34
- Number
- 12
- Start Page
- 1150
- End Page
- 1153
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115224
- DOI
- 10.1111/j.1525-1594.2009.00988.x
- ISSN
- 0160-564X
- Abstract
- Bone morphogenetic protein-2 (BMP-2) induces bone regeneration in a dose-dependent manner, with higher doses of BMP-2 inducing greater bone formation. Previously, we showed that long-term delivery of BMP-2 provides better ectopic bone formation than short-term delivery of an equivalent dose. In the present study, we investigated the efficacy of orthotopic bone formation over a range of BMP-2 doses, using different delivery modes. Heparin-conjugated poly(lactic-co-glycolic acid) nanospheres suspended in fibrin gel were used as a long-term delivery system, and fibrin gel was used as a short-term delivery system. Different doses of BMP-2 were delivered to mouse calvarial defects using either long-term or short-term delivery systems. Eight weeks after treatment, bone regeneration was evaluated by histomorphometry. For both delivery systems, bone regeneration increased as the BMP-2 dose increased up to 1 mu g and did not increase beyond this dose. Importantly, at BMP-2 doses higher than 1 mu g, long-term delivery resulted in much greater bone formation than short-term delivery. This study shows that long-term delivery of BMP-2 is more effective at enhancing orthotopic bone formation than short-term delivery over a range of doses.
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