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Adiponectin Concentrations: A Genome-wide Association Study

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dc.contributor.authorJee, Sun Ha-
dc.contributor.authorSull, Jae Woong-
dc.contributor.authorLee, Jong-Eun-
dc.contributor.authorShin, Chol-
dc.contributor.authorPark, Jongkeun-
dc.contributor.authorKimm, Heejin-
dc.contributor.authorCho, Eun-Young-
dc.contributor.authorShin, Eun-Soon-
dc.contributor.authorYun, Ji Eun-
dc.contributor.authorPark, Ji Wan-
dc.contributor.authorKim, Sang Yeun-
dc.contributor.authorLee, Sun Ju-
dc.contributor.authorJee, Eun Jung-
dc.contributor.authorBaik, Inkyung-
dc.contributor.authorKao, Linda-
dc.contributor.authorYoon, Sungjoo Kim-
dc.contributor.authorJang, Yangsoo-
dc.contributor.authorBeaty, Terri H.-
dc.date.accessioned2021-09-07T23:36:23Z-
dc.date.available2021-09-07T23:36:23Z-
dc.date.issued2010-10-08-
dc.identifier.issn0002-9297-
dc.identifier.issn1537-6605-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/115525-
dc.description.abstractAdiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage) Another 2,304 subjects were used for follow-up replication studies with selected markers In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1 69 x 10(-15) in the initial sample, p = 6.58 x 10(-39) in the second genome-wide sample, and p = 2.12 x 10(-32) in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2 82 x 10(-83) The association of rs3865188 with high-molecular-weight adiponectm (p = 7.36 x 10(-58)) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold This study clearly shows that genetic variants in CDH13 Influence adiponectm levels in Korean adults.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherCELL PRESS-
dc.titleAdiponectin Concentrations: A Genome-wide Association Study-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1016/j.ajhg.2010.09.004-
dc.identifier.scopusid2-s2.0-77957750180-
dc.identifier.wosid000283037600011-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF HUMAN GENETICS, v.87, no.4, pp 545 - 552-
dc.citation.titleAMERICAN JOURNAL OF HUMAN GENETICS-
dc.citation.volume87-
dc.citation.number4-
dc.citation.startPage545-
dc.citation.endPage552-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGenetics & Heredity-
dc.relation.journalWebOfScienceCategoryGenetics & Heredity-
dc.subject.keywordPlusHORMONE ADIPONECTIN-
dc.subject.keywordPlusINSULIN-RESISTANCE-
dc.subject.keywordPlusT-CADHERIN-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusOBESITY-
dc.subject.keywordPlusTRAITS-
dc.subject.keywordPlusFAT-
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